26 Mar 2021 In the Phase III VISION trial, 177Lu-PSMA-617 combined with the best available standard-of-care treatment improved both overall survival and

23 Mar 2021 Lu-PSMA-617, a targeted radioligand therapy, demonstrated The company also announced that results from the VISION trial will be

Lu-PSMA En randomiserad fas III studie pågår ”VISION”. – 68Ga-PSMA-11. – 177Lu-PSMA- 248 cykler 177Lu-PSMA-617 á 2-8 GBq (mean 5.9 GBq). Radioligandterapi (RLT) med Lu-177-märkt PSMA är ett lovande nytt terapeutiskt tillvägagångssätt för att behandla metastaserad prostatacancer. Denna prospektiv fas II studie En randomiserad fas III studie pågår VISION 68 Ga-PSMA Lu-PSMA-617 Sverige är med!» Stockholm, Lund, Göteborg, Uppsala, Umeå. First Clinical Experiences with Biograph Vision Quadra™ PET/CT dosimetry in 177 Lu-PSMA-617 therapy using a single post-treatment SPECT/CT scan.

Lu-psma-617 vision

23 Jul 2020 If the results of the ongoing, international phase III VISION trial on 177Lu-PSMA- 617 plus best standard of care versus only chemotherapy best First prospective trial with 177Lu-PSMA-617 in mCRPC. (Hofman et Lu-177 PSMA Small Molecule Studies VISION (177Lu-PSMA 617 vs Supportive/SOC). The purpose of this study is to compare overall survival (OS) in patients with progressive PSMA-positive mCRPC who receive 177Lu-PSMA-617 in addition to 177Lu-PSMA-617 (Lu-PSMA): radiolabelled small molecule binds to PSMA. • Delivers Results of upcoming phase 3 VISION trial (NCT03511664) pending. 18 Feb 2020 The full name for Lu-PSMA is 177 lutetium-PSMA-617; Lu-PSMA is an VISION Phase 3 study, the registration study for Lu-PSMA being 18 Oct 2018 Lu-PSMA-617 is currently being investigated in the Phase III global VISION clinical trial in men with mCRPC, a disease with limited treatment 15 Jul 2020 177Lu-PSMA-617 is in clinical development for patients with metastatic castration - resistant indication. The ongoing trial phase III clinical trial (VISION, NCT03511664) has an estimated treatment with 177-Lu-PSMA- 12 Feb 2019 PSMA-617 is a small molecule that binds to PSMA, and with 177Lu the VISION trial -- is testing the agent against best standard of care. 17 Aug 2020 By contrast, more cases of thrombocytopenia, dry mouth, and dry eye were reported in patients who received treatment with Lu-PSMA.

23 Mar 2021 The addition of the targeted radioligand therapy 177Lu-PSMA-617 to best cancer, meeting both primary end points of the phase 3 VISION trial. our belief in the potential of 177Lu-PSMA-617 to reimagine outcomes for&n

Methods: Patients were randomized 2:1 to receive best standard of care with or without 177 Lu-PSMA-617. 2021-03-23 2021-04-09 2020-02-16 2021-03-23 Our findings show that radionuclide treatment with [177Lu]-PSMA-617 has high response rates, low toxic effects, and reduction of pain in men with metastatic castration-resistant prostate cancer who have progressed after conventional treatments. This evidence supports the need for randomised controlled trials to further assess efficacy compared with current standards of care. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815.

2017-10-17 · The VISION trial will recruite > 700 patients.The goal is to evaluate whether Lu RLT will increase median overall survival from 10 to 13 months. It might seem a modest improval in survival but other established drugs of advanced prostate cancer had similar few months gain of median overall survival.

All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of (177) Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm(1) (7) . Endocyte has commenced a Phase III trial, VISION, to evaluate its Lu-PSMA-617 as a third-line treatment in patients suffering from progressive prostate-specific membrane antigen (PSA)-positive 2021-03-23 · In the Phase III VISION trial, researchers examined the efficacy and safety of 177 Lu-PSMA-617, an investigational PSMA-targeted radioligand therapy, in patients with advanced prostate cancer. The radioligand treatment approach from Novartis uses a targeting compound which can bind to markers expressed by tumors and a radioactive isotope. Lu-177-PSMA-617 had a PSA50 of 66% vs 37% for Jevtana; The percent who had PSA progression was 31% less in those getting Lu-177-PSMA-617 relative to those getting Jevtana 2017-10-05 · Endocyte announced it will move PSMA-617 quickly into Phase 3 development in prostate cancer after it licensed the compound from German ABX. The trial, for which the company has yet to seek approval, likely will launch by early 2018.

2 Seventeen (57%) patients achieved a prostate-specific antigen (PSA) decline ≥50%. [177Lu]Lu-PSMA-617 compared with cabazitaxel in men with metastatic castration-resistant prostate cancer led to a higher PSA response and fewer grade 3 or 4 adverse events. [177Lu]Lu-PSMA-617 is a new effective class of therapy and a potential alternative to cabazitaxel. 2021-03-23 · (RTTNews) - Swiss drug major Novartis AG (NVS) announced Tuesday positive result from its phase III VISION study evaluating the efficacy and safety of radioligand therapy 177Lu-PSMA-617 in 2017-02-06 · First U.S. Multi-center Investigational Clinical Trial of 177 Lu PSMA-617 Targeted Radioligand Therapy in Metastatic Castration Resistant Prostate Cancer Receives FDA Clearance 2021-03-23 · About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of ^177Lu-PSMA-617 (7.4 GBq administered by i.v VISION investigators aim to complete data collection for the primary outcome measures in May 2020. 11 Positive results from this trial could facilitate the FDA approval of 177 Lu-PSMA-617 for use in patients with mCRPC who have no or few treatment options.
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doi: 10.2967/jnumed.118.223149. Epub 2019 Mar 8.

This evidence supports the need for randomised controlled trials to further assess efficacy compared with current standards of care. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815.
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[177Lu]Lu-PSMA-617 compared with cabazitaxel in men with metastatic castration-resistant prostate cancer led to a higher PSA response and fewer grade 3 or 4 adverse events. [177Lu]Lu-PSMA-617 is a new effective class of therapy and a potential alternative to cabazitaxel.

[Epub ahead of print] Radioligand therapy using [177Lu]Lu-PSMA-617 in mCRPC: a pre-VISION single-center analysis. 2021-03-23 · In the international, prospective, open-label, multicenter VISION trial, investigators set out to compare OS in patients with progressive PSMA-positive mCRPC who receive 177 Lu-PSMA-617 plus best 2021-04-01 · An international phase 3 trial called VISION is looking at second-line 177 Lu-PSMA-617 versus docetaxel in those with CRPC who previously progressed on abiraterone (Zytiga) or enzalutamide. Azad says that 177 Lu-PSMA-617 has shown efficacy in metastatic CRPC in late-stage disease, and there are more data coming out in that area. DOI: 10.1007/s00259-020-04703-3 Corpus ID: 211127815.