Cantargia AB today announced that the IND application regarding the antibody CAN04 has been approved by the US FDA. CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development.
7 Jun 2018 The company is developing humanised, monoclonal antibody (CAN04) against IL1RAP, expecting to induce ADCC in the cancer cells.
Although conventional cancer therapeutic strategies, such as chemotherapy, radiation and surgery, have improved survival in patients with localized EWS tumours, they are ineffective for patients with metastatic disease. This subsequent new element, IL1RAP, became the focus of potential novel therapeutic strategies against cancer disease. But within the large family of cancers (more than 200 different members), Myeloid Leukemia (AML & CML) diseases show specificity. A specificity that turns out to be an obstacle to therapeutic treatment. 2. IL1RAP is expressed in a number of tumor tissues, including lung and pancreatic cancer, both on tumor cells and on infiltrating immune cells. We have, using antibodies directed against IL1RAP, shown the ability to target and kill IL1RAP-expressing tumor cells by ADCC, to inhibit IL-1 signaling in those cells and to reduce growth of transplanted human tumors in vivo.
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2019 Feb 1;79(3):663-675. doi: 10.1158/0008-5472.CAN-18-1078. 2020-07-23 · Cancer-Associated Mutations Selectively Impair Interactions with PTPRD Binding Partners, Related to Figure 5 Assessment of binding selectivity between individual members of the Butyrophilin, LRFN, SLITRK, IL1RAP and CNTN families and 8 PTPR family members (PTPRZ1, PTPRG, PTPRT, PTPRS, PTPRO, PTPRM, PTPRF and PTPRD) using the cell-based assay described in Figure 3 H. Expression of IL1RAP in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. 1. Leukemia. 2016 Jan;30(1):253-7.
Millares et al. Lung Cancer. 2018. 2. Ridker et al. Lancet 2017. 3. Wang et al. Cancer Res 2014. 4. McLoed et al. Cell Report 2016. 5.
2015-08-25 CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells Cancer Res . 2019 Feb 1;79(3):663-675. doi: 10.1158/0008-5472.CAN-18-1078. In addition, Cantargia also has patents on antibody therapy targeting IL1RAP in both solid tumors and in hematological cancer.
Cantargia utvecklar antikroppen CAN04 för behandling av cancer. CAN04 är riktad mot IL1RAP som finns på tumörceller från ett stort antal
Background: Interleukin 1 receptor Accessory protein, IL1RAP, is expressed in several solid tumors, both on cancer cells and tumor-associated inflammatory cells. CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP blocking IL-1 alpha and beta signaling and triggering antibody dependent cellular cytotoxicity.
Chronic tumor IL-1 signaling is involved in resistance to cancer therapies, immune evasion, and metastases. Interleukin-1 receptor associated protein (IL1RAP) is a co-receptor of the IL-1 receptor (IL1R1) and the IL-33 receptor (ST2) and is required for signaling through both receptor complexes. We have previously described IL1RAP as a cancer target on leukemic cells and shown that antibodies directed against
Interleukin-1 receptor associated protein (IL1RAP) is a co-receptor of the IL-1 receptor (IL1R1) and is required for IL-1 signaling.
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Although conventional cancer therapeutic strategies, such as chemotherapy, radiation and surgery, have improved survival in patients with localized EWS tumours, they are ineffective for patients with metastatic disease. This subsequent new element, IL1RAP, became the focus of potential novel therapeutic strategies against cancer disease.
Cancer Res 2014. 4. McLoed et al.
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Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms
18 May 2018 Researchers are currently developing ways to prompt a patient's own immune cells to selectively recognise and kill IL1RAP-expressing cancer 13 Nov 2019 IntroductionOne of the contributing factors to the relapse of acute myeloid leukemia (AML) is the presence of leukemia stem cells (LSCs). 8 Apr 2020 The antibody CAN04 binds IL1RAP with high affinity and its anti-tumor activity consists both of stimulation of immune cells to eradicate cancer 7 Feb 2019 The anti-IL1RAP antibodies provided herein are, inter alia, useful for the treatment of IL1RAP-expressing cancers such as AML. # - 7 Nov 2019 Background: Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide. However, the key roles of most molecules 1 jun 2019 Millares et al. Lung Cancer. 2018. 2. Ridker et al.